Cyra-D (Domperidone 30mg + Rabeprazole 20mg)

Cyra-D Capsule is a prescription medication combining Domperidone 30 mg (10 mg immediate-release and 20 mg sustained-release) and Rabeprazole 20 mg (as enteric-coated pellets). Manufactured by companies like Systopic Laboratories Pvt. Ltd. or Mepro Pharmaceuticals Pvt. Ltd., it is available in strips of 10 capsules. This combination is used to manage acid-related digestive disorders, primarily gastroesophageal reflux disease (GERD) and peptic ulcers. It alleviates symptoms like heartburn, nausea, and bloating by reducing stomach acid and improving digestive motility. Cyra-D is suitable for adults and requires medical supervision due to potential side effects and interactions.

Uses

Cyra-D Capsule is used for:

• Treating gastroesophageal reflux disease (GERD), relieving symptoms like heartburn, acid reflux, and chest discomfort

• Managing peptic ulcer disease, including gastric and duodenal ulcers

• Alleviating acid-related indigestion and nausea

• Supporting treatment of Zollinger-Ellison syndrome (excess acid production due to pancreatic tumors)

• Controlling nausea and vomiting associated with excess stomach acid

• Facilitating digestion by reducing bloating and improving gastric motility

Side Effects

Cyra-D Capsule may cause:

• Common: Diarrhea, stomach pain, dry mouth, headache, dizziness, nausea, constipation, flatulence, cough, insomnia, weakness

• Rare: Allergic reactions (rash, itching, swelling), abnormal heartbeat, inflammation of the nose, back pain, pharyngitis

• Serious: Severe allergic reactions (difficulty breathing, throat tightness), irregular heart rhythms (QT prolongation), seizures, or signs of dehydration from persistent diarrhea

Consult a doctor if side effects persist or worsen. Seek immediate medical help for severe symptoms like chest pain or breathing difficulties.

How to Use

• Dosage: Take 1 capsule daily, typically in the morning, or as prescribed by your doctor. Dosage may vary based on condition and response.

• Administration: Swallow the capsule whole with water, 15–30 minutes before a meal (preferably breakfast) for optimal absorption. Do not crush, chew, or break the capsule.

• Duration: Continue for the prescribed duration, even if symptoms improve. Do not stop abruptly without consulting your doctor.

• Overdose: Seek immediate medical help for symptoms like severe dizziness, confusion, or irregular heartbeat.

How Capsule Works

Cyra-D Capsule combines two active ingredients:

• Domperidone: A prokinetic agent that enhances upper gastrointestinal motility by increasing stomach and intestinal contractions, allowing food to move more easily and reducing nausea and vomiting by blocking dopamine receptors in the brain’s chemoreceptor trigger zone.

• Rabeprazole: A proton pump inhibitor (PPI) that reduces stomach acid production by inhibiting the H+/K+ ATPase enzyme in parietal cells, alleviating acid-related damage to the esophagus, stomach, and duodenum.

Together, they provide rapid relief from acid reflux, heartburn, and digestive discomfort, promoting healing of ulcers and improving digestion. Effects are typically noticeable within 1 hour and last up to 24 hours.

Safety Advice

• Allergies: Avoid if allergic to Domperidone, Rabeprazole, or any capsule ingredients (e.g., gelatin, red oxide of iron, tartrazine yellow).

• Health Conditions: Use with caution in patients with liver or kidney disease, heart conditions (e.g., heart failure, QT prolongation), electrolyte imbalances, or prolactinoma (pituitary tumor), as Domperidone may increase prolactin levels.

• Drug Interactions: May interact with blood thinners (e.g., warfarin), antifungals (e.g., ketoconazole), antivirals (e.g., atazanavir), or anti-epileptics (e.g., phenytoin). Inform your doctor of all medications.

• Pregnancy/Breastfeeding: Likely unsafe; animal studies show potential fetal harm, and Domperidone may pass into breast milk. Consult a doctor before use.

• Driving: May cause dizziness or drowsiness; avoid driving or operating machinery if affected.

• Alcohol: Limit alcohol, as it may worsen side effects or increase stomach irritation.

• Storage: Store below 30°C in a cool, dry place, away from sunlight and out of reach of children.

• Children: Not recommended for children under 12 unless prescribed by a doctor.

• Additional Precautions: Avoid spicy, fatty, or caffeinated foods. Do not lie down immediately after taking the capsule. Long-term use may require monitoring for bone health, magnesium, or vitamin B12 levels.