Flagyl 400 (Metronidazole 400 mg)

Flagyl 400 mg Tablet, containing Metronidazole 400 mg, is a prescription antibiotic and antiprotozoal drug by Abbott India Ltd. Available in strips of 15 tablets, it treats bacterial and parasitic infections in adults and children. Requires a prescription due to risks of side effects and drug interactions.

Uses

• Treats bacterial infections (e.g., dental, skin, respiratory, pelvic inflammatory disease)

• Manages parasitic infections (e.g., amoebiasis, giardiasis, trichomoniasis)

• Prevents post-surgical infections

• Treats Helicobacter pylori infections (with other drugs)

Side Effects

• Common: Nausea, vomiting, diarrhea, metallic taste, headache, dizziness

• Rare: Dry mouth, rash, dark urine, fatigue

• Serious: Seizures, peripheral neuropathy (numbness/tingling), allergic reactions (e.g., rash, swelling, breathing difficulty), liver dysfunction (e.g., jaundice)

Seek emergency help for seizures, severe rash, or breathing issues. Consult a doctor for persistent side effects.

How to Use

• Dosage: Adults: 400 mg 2–3 times daily for 5–10 days, as prescribed. Children: Dose based on weight (7.5 mg/kg every 8 hours). Follow doctor’s instructions.

• Administration: Swallow whole with water, with food to reduce stomach upset. Do not crush/chew.

• Missed Dose: Take as soon as remembered unless near next dose. Do not double dose.

• Overdose: Seek urgent help for nausea, seizures, or coordination loss. Call Poison Help (1-800-222-1222).

How Tablet Works

Metronidazole disrupts DNA synthesis in anaerobic bacteria and protozoa, killing them. Effective against infections like Clostridium difficile, Entamoeba histolytica, and Trichomonas vaginalis. Absorbed rapidly, peaking in 1–2 hours, with a half-life of ~8 hours. Excreted via urine (60–80%) and feces.

Safety Advice

• Allergies: Avoid if allergic to Metronidazole or nitroimidazoles.

• Health Conditions: Contraindicated in first trimester of pregnancy or with active neurological disorders. Caution in liver disease, kidney issues, or blood disorders.

• Drug Interactions: Increases bleeding risk with Eliquis (Apixaban). Avoid with alcohol (disulfiram-like reaction: nausea, flushing).

• Pregnancy/Breastfeeding: Avoid in first trimester; use only if essential later. Excreted in breast milk; consult doctor.

• Driving: Avoid if dizzy or experiencing seizures.

• Alcohol: Strictly avoid alcohol during and 48 hours after treatment; causes severe nausea.

• Storage: Store at 15–30°C, away from moisture, light, and children.